Trifluoroacetic acid → 1-Ethynylcyclopropane-1-sulfonamide
반응식
C([NH:8][S:9]([C:12]1([C:15]#[CH:16])[CH2:14][CH2:13]1)(=[O:11])=[O:10])(OC(C)(C)C)=O.C(O)(C(F)(F)F)=O>C(Cl)Cl>[C:15]([C:12]1([S:9]([NH2:8])(=[O:11])=[O:10])[CH2:14][CH2:13]1)#[CH:16]참가 물질
4
실험 절차
A mixture of compound 81 (200 mg, 0.81 mmol) and TFA (0.3 mL) in DCM (5 mL) was stirred at room temperature for 16 hrs. The reaction mixture was concentrated under reduced pressure and the crude material was purified by chromatography on silica gel (MeOH/DCM) to yield compound 82 in 70% yield.
후처리
- concentrationThe reaction mixture was concentrated under reduced pressure
- customthe crude material was purified by chromatography on silica gel (MeOH/DCM)
출처 및 근거
- ORD 기록
- ord-a8325344332548a1a64e8bf36c3da0b4
- 출처 데이터셋
- uspto-grants-2011_08
- 특허 번호
- US08003659B2
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