홈MCP워크벤치Skills
홈워크벤치알림마이페이지
llms.txt · MCP 가이드개인정보처리방침 · 이용약관 · 지원v1.8.0
  1. 홈
  2. /반응

Acetyl chloride → Cyclopropanecarboxamide, 1-amino-2-ethenyl-N-[(1-methylcyclopropyl)sulfonyl]-, hydrochloride (1:1), (1R,2S)-

HRID 1675445
노트
인쇄 미리보기

반응식

HRID 1675445 반응식
[CH3:1][C:2]1([S:5]([NH:8][C:9]([C@@:11]2([NH:16]C(=O)OC(C)(C)C)[CH2:13][C@H:12]2[CH:14]=[CH2:15])=[O:10])(=[O:7])=[O:6])[CH2:4][CH2:3]1.C([Cl:27])(=O)C>CO>[ClH:27].[NH2:16][C@:11]1([C:9]([NH:8][S:5]([C:2]2([CH3:1])[CH2:4][CH2:3]2)(=[O:7])=[O:6])=[O:10])[CH2:13][C@H:12]1[CH:14]=[CH2:15]
참가 물질반응 조건실험 절차후처리출처 및 근거반응 노트

참가 물질

4

반응물 2

HCID 6367Acetyl chlorideHCID 56605353tert-butyl [(1R,2S)-2-ethenyl-1-{[(1-methylcyclopropyl)sulfonyl]carbamoyl}cyclopropyl]carbamate

생성물 1

HCID 66650595Cyclopropanecarboxamide, 1-amino-2-ethenyl-N-[(1-methylcyclopropyl)sulfonyl]-, hydrochloride (1:1), (1R,2S)-수율 102%

시약·촉매·용매 1

HCID 887Methanol용매2회

반응 조건

온도
50 °C
이 페이지에서참가 물질반응 조건실험 절차후처리출처 및 근거반응 노트

실험 절차

Compound 122 (51.5 g) was suspended in methanol (150 mL). A solution of acetyl chloride (3 eq.) in methanol was added to the suspension. The reaction mixture was heated at 50° C. for 3 hrs. The reaction mixture was concentrated at 45-50° C. and co-evaporated with DCM to give compound 123 (42.4 g) as a white powder in 102% yield due to DCM.

후처리

  1. concentrationThe reaction mixture was concentrated at 45-50° C. and co-evaporated with DCM

출처 및 근거

ORD 기록
ord-6848494d0b844cec8fd6be1e929d87e1
출처 데이터셋
uspto-grants-2011_08
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US08003659B2

반응 노트

불러오는 중…