Dibromomethane → 4-(2-(5-bromo-4-(2-chloro-4-cyclopropyl-6-methylphenyl)-4H-1,2,4-triazol-3-ylthio)acetamido)-3-chlorobenzoic acid

HRID 1675481

반응식

HRID 1675481 반응식
ClC(Cl)C(O)=O.N[C:8]1[N:9]([C:28]2[C:33]([CH3:34])=[CH:32][C:31]([CH:35]3[CH2:37][CH2:36]3)=[CH:30][C:29]=2[Cl:38])[C:10]([S:13][CH2:14][C:15]([NH:17][C:18]2[CH:26]=[CH:25][C:21]([C:22]([OH:24])=[O:23])=[CH:20][C:19]=2[Cl:27])=[O:16])=[N:11][N:12]=1.N([O-])=O.[Na+].ClCCl.[Br:46]CBr>[Br-].C([N+](CC)(CC)CC)C1C=CC=CC=1>[Br:46][C:8]1[N:9]([C:28]2[C:33]([CH3:34])=[CH:32][C:31]([CH:35]3[CH2:37][CH2:36]3)=[CH:30][C:29]=2[Cl:38])[C:10]([S:13][CH2:14][C:15]([NH:17][C:18]2[CH:26]=[CH:25][C:21]([C:22]([OH:24])=[O:23])=[CH:20][C:19]=2[Cl:27])=[O:16])=[N:11][N:12]=1

참가 물질

7

반응물 5

HCID 3024DibromomethaneHCID 6344DichloromethaneHCID 6597Dichloroacetic AcidHCID 23668193Sodium NitriteHCID 598130994-(2-(5-amino-4-(2-chloro-4-cyclopropyl-6-methylphenyl)-4H-1,2,4-triazol-3-ylthio)acetamido)-3-chlorobenzoic acid

생성물 1

HCID 162218154-(2-(5-bromo-4-(2-chloro-4-cyclopropyl-6-methylphenyl)-4H-1,2,4-triazol-3-ylthio)acetamido)-3-chlorobenzoic acid수율 42%

시약·촉매·용매 1

HCID 165294Benzyltriethylammonium bromide촉매

실험 절차

Dichloroacetic acid (0.065 mL, 0.78 mmol) was added to a mixture of compound 6 (192 mg, 0.39 mmol), benzyltriethyl ammonium bromide (318 mg, 1.17 mmol) and sodium nitrite (538 mg, 7.8 mmol) in dibromomethane (10 mL). The mixture was stirred at room temperature for 18 hours in the dark. The reaction mixture was then concentrated and the resulting residue was purified by prep. TLC (95% dichloromethane/5% methanol) to afford 88 mg, 42% yield of 4-(2-(5-bromo-4-(2-chloro-4-cyclopropyl-6-methylphenyl)-4H-1,2,4-triazol-3-ylthio)acetamido)-3-chlorobenzoic acid (7).

후처리

  1. concentrationThe reaction mixture was then concentrated
  2. customthe resulting residue was purified by prep

출처 및 근거

ORD 기록
ord-736420fe1835452aa61836b1816aa175
출처 데이터셋
uspto-grants-2011_08
특허 번호
US08003681B2

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