Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Glutaric anhydride → 4-[(4-Ethynylphenyl)carbamoyl]butanoic acid
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Glutaric anhydride | HCID 7940 | — |
| 반응물 | 4-Ethynylaniline | HCID 3760025 | — |
| 용매 | Dichloromethane | HCID 6344 | — |
| 생성물 | 4-[(4-Ethynylphenyl)carbamoyl]butanoic acid | HCID 24826477 | — |
반응 단계
To a solution of 4-ethynylaniline (0.99 g, 8.5 mmol) in CH2Cl2(100 ml) is added glutaric anhydride (1.06 g, 9.30 mmol). After 1 h, the resulting slurry is concentrated by rotary evaporation and the crude mixture is purified by silica column chromatography (10% methanol/5% TEA/CH2Cl2).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08003771B2 |
| 출처 데이터셋 | uspto-grants-2011_08 |
| ORD ID | ord-31d706acbe9e4d8d80eee56a97836d66 |
| 출처 메모 | uspto-grants-2011_08 |