Ethyl 4-[(2-nitrophenyl)amino]benzoate → Ethyl 4-[(2-aminophenyl)amino]benzoate

HRID 1675773노트

반응식

HRID 1675773 반응식
[N+:1]([C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][C:5]=1[NH:10][C:11]1[CH:21]=[CH:20][C:14]([C:15]([O:17][CH2:18][CH3:19])=[O:16])=[CH:13][CH:12]=1)([O-])=O>CCO.[Pd]>[NH2:1][C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][C:5]=1[NH:10][C:11]1[CH:21]=[CH:20][C:14]([C:15]([O:17][CH2:18][CH3:19])=[O:16])=[CH:13][CH:12]=1

참가 물질

4

반응물 1

HCID 11208411Ethyl 4-[(2-nitrophenyl)amino]benzoate

생성물 1

HCID 18449398Ethyl 4-[(2-aminophenyl)amino]benzoate

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 702Ethanol용매

실험 절차

A mixture of ethyl 4-[(2-nitrophenyl)amino]benzoate from Step A (755 mg, 2.64 mmol) and 10% Pd/C (505 mg) in EtOH (25 mL) was stirred under an atmosphere of hydrogen (ca. 1 atm) for 4 h. The mixture was filtered through a pad of Celite, washing with EtOH, and the filtrate was concentrated to give the title compound. MS: m/z=257 (M+1).

후처리

  1. filtrationThe mixture was filtered through a pad of Celite
  2. washwashing with EtOH
  3. concentrationthe filtrate was concentrated

출처 및 근거

ORD 기록
ord-8b9c4d2eaa5d4810bae224ffe5982691
출처 데이터셋
uspto-grants-2011_08
특허 번호
US08003792B2

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