Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
1H-1,2,4-Triazole → 4-(1,2,4-Triazol-1-ylmethyl)benzonitrile
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 1H-1,2,4-Triazole | HCID 9257 | — |
| 반응물 | 4-(Bromomethyl)benzonitrile | HCID 86996 | — |
| 생성물 | 4-(1,2,4-Triazol-1-ylmethyl)benzonitrile | HCID 7537616 | — |
반응 단계
U.S. Pat. No. 4,978,672 discloses 4-[alpha-(4-cyanophenyl)-1-(1,2,4-triazolyl)-methyl]benzonitrile and a process for its preparation comprising reacting 4-bromomethyl benzonitrile with 1,2,4-triazole to yield 4-[1-(1,2,4-triazol-1-yl)methyl]benzonitrile. 4-[1-(1,2,4-triazol-1-yl)methyl]benzonitrile is then reacted with 4-fluorobenzonitrile to give 4-[1-(4-cyanophenyl)-1-(1,2,4-triazol-1-yl)methyl]benzonitrile (letrozole).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08003804B2 |
| 출처 데이터셋 | uspto-grants-2011_08 |
| ORD ID | ord-72187d5fdcde46e3bfaf5b295dcae26e |
| 출처 메모 | uspto-grants-2011_08 |