Diisopropylamine → HCID 66704174, 화합물

HRID 1675935노트

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HRID 1675935 반응식
[O:1]=[C:2]1[C@@:6]([N:12]2[CH:16]=[CH:15][CH:14]=[CH:13]2)([C:7]([O:9][CH2:10][CH3:11])=[O:8])[CH2:5][C:4](=[O:17])[NH:3]1.[CH:18]([NH:21][CH:22]([CH3:24])[CH3:23])([CH3:20])[CH3:19].CCCCCC>C(OCC)(=O)C>[CH:18]([NH:21][CH:22]([CH3:24])[CH3:23])([CH3:20])[CH3:19].[O:1]=[C:2]1[C@@:6]([N:12]2[CH:13]=[CH:14][CH:15]=[CH:16]2)([C:7]([O:9][CH2:10][CH3:11])=[O:8])[CH2:5][C:4](=[O:17])[NH:3]1

참가 물질

5

반응물 3

HCID 7912DiisopropylamineHCID 8058HexaneHCID 10823690Ethyl (3R)-2,5-dioxo-3-(1H-pyrrol-1-yl)-3-pyrrolidinecarboxylate

생성물 1

HCID 66704174HCID 66704174, 화합물수율 60%

시약·촉매·용매 1

HCID 8857Ethyl Acetate용매

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온도
40 °C

실험 절차

Ethyl (R)-2,5-dioxo-3-(pyrrol-1-yl)pyrrolidine-3-carboxylate (220 mg) was dissolved in ethyl acetate (1 ml) and thereto was added diisopropylamine (0.130 ml). To this solution was added hexane (1 ml) and the resulting white suspension was warmed at 40° C. to give a homogeneous solution. This mixture was allowed to stand at room temperature and precipitated crystal was collected by filtering to give ethyl (R)-2.5-dioxo-3-(pyrrol-1-yl)pyrrolidine-3-carboxylate diisopropylamine salt (198 mg, 60%) as crystal.

후처리

  1. customto give a homogeneous solution
  2. customto stand at room temperature
  3. customprecipitated crystal
  4. customwas collected
  5. filtrationby filtering

출처 및 근거

ORD 기록
ord-1f9bd8cad2444227850e5b8b6f268b4b
출처 데이터셋
uspto-grants-2011_08
특허 번호
US08003808B2

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