(S)-tert-butyl-5-(nitrooxy)hexanoate → (S)-5-(nitrooxy)hexanoic acid

HRID 1676010노트

반응식

HRID 1676010 반응식
C([O:5][C:6](=[O:16])[CH2:7][CH2:8][CH2:9][C@@H:10]([O:12][N+:13]([O-:15])=[O:14])[CH3:11])(C)(C)C>C(Cl)Cl>[N+:13]([O:12][C@@H:10]([CH3:11])[CH2:9][CH2:8][CH2:7][C:6]([OH:16])=[O:5])([O-:15])=[O:14]

참가 물질

3

반응물 1

HCID 58231672(S)-tert-butyl-5-(nitrooxy)hexanoate

생성물 1

HCID 58231663(S)-5-(nitrooxy)hexanoic acid

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

(S)-tert-butyl-5-(nitrooxy)hexanoate (590 mg, 2.53 mmol), was dissolved in CH2Cl2 (20 mL). HClgas was bubbled into the solution until the disappearance of the starting material. The solution was reduced to a small volume and diluted in CH2Cl2 few times to remove residual acidity, then used without further purification.

후처리

  1. customHClgas was bubbled into the solution until the disappearance of the starting material
  2. additiondiluted in CH2Cl2 few times
  3. customto remove residual acidity
  4. customused without further purification

출처 및 근거

ORD 기록
ord-484fde50b49a4e15a7d1d02cdd4e4e35
출처 데이터셋
uspto-grants-2011_08
특허 번호
US08003811B2

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