4-Isobutyl-3,5-dimethylthiophene-2-carboxylic acid → 2-Ethyl-4-[5-(4-isobutyl-3,5-dimethyl-thiophen-2-yl)-[1,2,4]oxadiazol-3-yl]-6-methyl-phenol
반응식
[CH2:1]([C:5]1[C:6]([CH3:14])=[C:7]([C:11]([OH:13])=O)[S:8][C:9]=1[CH3:10])[CH:2]([CH3:4])[CH3:3].[OH:15][C:16]1[C:25]([CH3:26])=[CH:24][C:19]([C:20]([NH:22]O)=[NH:21])=[CH:18][C:17]=1[CH2:27][CH3:28]>>[CH2:27]([C:17]1[CH:18]=[C:19]([C:20]2[N:22]=[C:11]([C:7]3[S:8][C:9]([CH3:10])=[C:5]([CH2:1][CH:2]([CH3:3])[CH3:4])[C:6]=3[CH3:14])[O:13][N:21]=2)[CH:24]=[C:25]([CH3:26])[C:16]=1[OH:15])[CH3:28]참가 물질
3
실험 절차
2-Ethyl-4-[5-(4-isobutyl-3,5-dimethyl-thiophen-2-yl)-[1,2,4]oxadiazol-3-yl]-6-methyl-phenol is prepared in analogy to Example 21 starting from 4-isobutyl-3,5-dimethyl-thiophene-2-carboxylic acid and 4,N-dihydroxy-3-ethyl-5-methyl-benzamidine; LC-MS: tR=1.20 min, [M+1]=371.04.
출처 및 근거
- ORD 기록
- ord-9a4efffcbafd4041b37abb3fa2fb0c12
- 출처 데이터셋
- uspto-grants-2011_08