3-isopropoxy-N-(1-methyl-piperidin-4-yl)-4-nitro-benzamide → 4-amino-3-isopropoxy-N-(1-methyl-piperidin-4-yl)-benzamide

HRID 1676534노트

반응식

HRID 1676534 반응식
[CH:1]([O:4][C:5]1[CH:6]=[C:7]([CH:18]=[CH:19][C:20]=1[N+:21]([O-])=O)[C:8]([NH:10][CH:11]1[CH2:16][CH2:15][N:14]([CH3:17])[CH2:13][CH2:12]1)=[O:9])([CH3:3])[CH3:2].[H][H]>CO.[Pd]>[NH2:21][C:20]1[CH:19]=[CH:18][C:7]([C:8]([NH:10][CH:11]2[CH2:12][CH2:13][N:14]([CH3:17])[CH2:15][CH2:16]2)=[O:9])=[CH:6][C:5]=1[O:4][CH:1]([CH3:3])[CH3:2]

참가 물질

5

반응물 2

HCID 670764013-isopropoxy-N-(1-methyl-piperidin-4-yl)-4-nitro-benzamideHCID 178418361HCID 178418361, 화합물

생성물 1

HCID 580149994-amino-3-isopropoxy-N-(1-methyl-piperidin-4-yl)-benzamide수율 95.3%

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 887Methanol용매

실험 절차

To a solution of 1.2 g (3.6 mmole) of 3-isopropoxy-N-(1-methyl-piperidin-4-yl)-4-nitro-benzamide in 25 mL of methanol was added 0.12 g of 10% palladium on carbon. The hydrogenation reaction was carried out under 50 psi of hydrogen for 2 hours. The mixture was filtered, concentrated under reduced pressure and triturated with ether. The solid was collected by filtration, washed with ether and dried under vacuum to give 1.0 g of 4-amino-3-isopropoxy-N-(1-methyl-piperidin-4-yl)-benzamide as a white solid.

후처리

  1. customThe hydrogenation reaction
  2. filtrationThe mixture was filtered
  3. concentrationconcentrated under reduced pressure
  4. customtriturated with ether
  5. filtrationThe solid was collected by filtration
  6. washwashed with ether
  7. customdried under vacuum

출처 및 근거

ORD 기록
ord-695d0ef61d084dc6ab4ef81caf607ec8
출처 데이터셋
uspto-grants-2011_08
특허 번호
US08003785B2

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