Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Azosemide → 5-[1-(t-Butylcarbonyloxymethyl)-1H-tetrazol-5-yl]-2-chloro-4-[(2-thienylmethyl)amino]benzenesulfonamide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Azosemide | HCID 2273 | — |
| 반응물 | Sodium Iodide | HCID 5238 | — |
| 반응물 | Triethylamine | HCID 8471 | — |
| 반응물 | Chloromethyl pivalate | HCID 87885 | — |
| 용매 | Dimethylformamide | HCID 6228 | — |
| 생성물 | 5-[1-(t-Butylcarbonyloxymethyl)-1H-tetrazol-5-yl]-2-chloro-4-[(2-thienylmethyl)amino]benzenesulfonamide | HCID 60208421 | — |
반응 단계
In a similar manner to Example 12, azosemide can be reacted with chloromethyl pivalate, triethylamine and sodium iodide in DMF to yield 5-[1-(t-Butylcarbonyloxymethyl)-1H-tetrazol-5-yl]-2-chloro-4-[(2-thienylmethyl)amino]benzenesulfonamide.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08008283B2 |
| 출처 데이터셋 | uspto-grants-2011_08 |
| ORD ID | ord-0c1dfbcca0684062a244ca47d8938754 |
| 출처 메모 | uspto-grants-2011_08 |