Azosemide → 2-chloro-5-[1-(ethylcarbonyloxymethyl)-1H-tetrazol-5-yl]-4-[(2-thienylmethyl)amino]benzenesulfonamide

HRID 1676936

반응식

HRID 1676936 반응식
[CH:1]1[CH:2]=[C:3]([CH2:6][NH:7][C:8]2[C:13]([C:14]3[N:18]=[N:17][NH:16][N:15]=3)=[CH:12][C:11]([S:19]([NH2:22])(=[O:21])=[O:20])=[C:10]([Cl:23])[CH:9]=2)[S:4][CH:5]=1.[C:24]([O:28][CH2:29]Cl)(=[O:27])[CH2:25][CH3:26].C(N(CC)CC)C.[I-].[Na+]>CN(C=O)C>[Cl:23][C:10]1[CH:9]=[C:8]([NH:7][CH2:6][C:3]2[S:4][CH:5]=[CH:1][CH:2]=2)[C:13]([C:14]2[N:15]([CH2:29][O:28][C:24]([CH2:25][CH3:26])=[O:27])[N:16]=[N:17][N:18]=2)=[CH:12][C:11]=1[S:19]([NH2:22])(=[O:21])=[O:20]

참가 물질

6

반응물 4

HCID 2273AzosemideHCID 5238Sodium IodideHCID 8471TriethylamineHCID 221144Chloromethyl propionate

생성물 1

HCID 602084222-chloro-5-[1-(ethylcarbonyloxymethyl)-1H-tetrazol-5-yl]-4-[(2-thienylmethyl)amino]benzenesulfonamide

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

In similar manner to Example 12, azosemide can be reacted with chloromethyl propionate, triethylamine and sodium iodide in DMF to yield 2-chloro-5-[1-(ethylcarbonyloxymethyl)-1H-tetrazol-5-yl]-4-[(2-thienylmethyl)amino]benzenesulfonamide.

출처 및 근거

ORD 기록
ord-df422ec5a938464195bf4e267dcdbce1
출처 데이터셋
uspto-grants-2011_08
특허 번호
US08008283B2

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