Formaldehyde → 2-chloro-5-[1-(methoxymethyl)-1H-tetrazol-5-yl]-4-[(2-thienylmethyl)amino]benzenesulfonamide

HRID 1676938

반응식

HRID 1676938 반응식
[CH:1]1[CH:2]=[C:3]([CH2:6][NH:7][C:8]2[C:13]([C:14]3[N:18]=[N:17][NH:16][N:15]=3)=[CH:12][C:11]([S:19]([NH2:22])(=[O:21])=[O:20])=[C:10]([Cl:23])[CH:9]=2)[S:4][CH:5]=1.[CH2:24]=O.CO.CN([CH:31]=[O:32])C>C(Cl)Cl.C(Cl)Cl.CN(C=O)C>[Cl:23][C:10]1[CH:9]=[C:8]([NH:7][CH2:6][C:3]2[S:4][CH:5]=[CH:1][CH:2]=2)[C:13]([C:14]2[N:15]([CH2:24][O:32][CH3:31])[N:16]=[N:17][N:18]=2)=[CH:12][C:11]=1[S:19]([NH2:22])(=[O:21])=[O:20]

참가 물질

7

반응물 4

HCID 712FormaldehydeHCID 887MethanolHCID 2273AzosemideHCID 6228Dimethylformamide

생성물 1

HCID 602084242-chloro-5-[1-(methoxymethyl)-1H-tetrazol-5-yl]-4-[(2-thienylmethyl)amino]benzenesulfonamide

시약·촉매·용매 2

HCID 6344Dichloromethane용매HCID 22350042dichloromethane N,N-dimethylformamide용매

실험 절차

Azosemide can be reacted with formaldehyde and methanol in methylene chloride, methylene chloride-DMF mixtures or DMF to yield 2-chloro-5-[1-(methoxymethyl)-1H-tetrazol-5-yl]-4-[(2-thienylmethyl)amino]benzenesulfonamide.

출처 및 근거

ORD 기록
ord-7ceeb4da574547eea44c16bac3e0b78e
출처 데이터셋
uspto-grants-2011_08
특허 번호
US08008283B2

연결된 노트

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