(3R,5R)-3-acetyl-5-(3,4,5-trifluorophenyl)morpholine-4-carboxylic acid benzyl ester → 1-[(3R,5R)-5-(3,4,5-trifluorophenyl)morpholin-3-yl]ethanone

HRID 1677092노트

반응식

HRID 1677092 반응식
C(OC([N:11]1[C@H:16]([C:17]2[CH:22]=[C:21]([F:23])[C:20]([F:24])=[C:19]([F:25])[CH:18]=2)[CH2:15][O:14][CH2:13][C@@H:12]1[C:26](=[O:28])[CH3:27])=O)C1C=CC=CC=1>[Pd].C(O)C>[F:23][C:21]1[CH:22]=[C:17]([C@H:16]2[NH:11][C@@H:12]([C:26](=[O:28])[CH3:27])[CH2:13][O:14][CH2:15]2)[CH:18]=[C:19]([F:25])[C:20]=1[F:24]

참가 물질

4

반응물 1

HCID 67372176(3R,5R)-3-acetyl-5-(3,4,5-trifluorophenyl)morpholine-4-carboxylic acid benzyl ester

생성물 1

HCID 673707471-[(3R,5R)-5-(3,4,5-trifluorophenyl)morpholin-3-yl]ethanone수율 100.3%

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 702Ethanol용매

실험 절차

An ethanol (15 mL) suspension of 10% palladium on carbon (50% water contain, 79.2 mg) and (3R,5R)-3-acetyl-5-(3,4,5-trifluorophenyl)morpholin-4-carboxylic acid benzyl ester (800 mg) was stirred for 15 minutes under a hydrogen atmosphere. The catalyst was separated by filtration on celite. The filtrate was concentrated, and the title compound (529 mg) was obtained. The physical property values are as follows.

후처리

  1. customThe catalyst was separated by filtration on celite
  2. concentrationThe filtrate was concentrated

출처 및 근거

ORD 기록
ord-71b871b6d44d42a2b1c37712270cecc1
출처 데이터셋
uspto-grants-2011_08
특허 번호
US08008293B2

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