Dimethylformamide → 5-(Benzo[d][1,3]dioxol-5-yl)-3-{6-[3-benzyl-8-(trifluoromet hyl)quinolin-4-yloxy]hexyl}-5-methylimidazolidine-2,4-dione

HRID 1677125노트

반응식

HRID 1677125 반응식
CN(C=O)C.[CH2:6]([C:13]1[CH:14]=[N:15][C:16]2[C:21]([C:22]=1[O:23][CH2:24][CH2:25][CH2:26][CH2:27][CH2:28][CH2:29]Br)=[CH:20][CH:19]=[CH:18][C:17]=2[C:31]([F:34])([F:33])[F:32])[C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1.C(=O)([O-])[O-].[K+].[K+].[O:41]1[C:45]2[CH:46]=[CH:47][C:48]([C:50]3([CH3:57])[NH:54][C:53](=[O:55])[NH:52][C:51]3=[O:56])=[CH:49][C:44]=2[O:43][CH2:42]1>O>[O:41]1[C:45]2[CH:46]=[CH:47][C:48]([C:50]3([CH3:57])[NH:54][C:53](=[O:55])[N:52]([CH2:29][CH2:28][CH2:27][CH2:26][CH2:25][CH2:24][O:23][C:22]4[C:21]5[C:16](=[C:17]([C:31]([F:34])([F:33])[F:32])[CH:18]=[CH:19][CH:20]=5)[N:15]=[CH:14][C:13]=4[CH2:6][C:7]4[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=4)[C:51]3=[O:56])=[CH:49][C:44]=2[O:43][CH2:42]1

참가 물질

6

반응물 4

HCID 6228DimethylformamideHCID 11430Potassium CarbonateHCID 28298175-(2H-1,3-benzodioxol-5-yl)-5-methylimidazolidine-2,4-dioneHCID 668707273-Benzyl-4-(6-bromohexyloxy)-8-(trifluoromethyl)quinoline

생성물 1

HCID 444627495-(Benzo[d][1,3]dioxol-5-yl)-3-{6-[3-benzyl-8-(trifluoromet hyl)quinolin-4-yloxy]hexyl}-5-methylimidazolidine-2,4-dione수율 121%

시약·촉매·용매 1

HCID 962Water용매

실험 절차

A DMF (0.1 mL) solution of 3-benzyl-4-(6-bromohexyloxy)-8-(trifluoromethyl)quinoline (12.5 mg, 0.03 mmol) was added with potassium carbonate (9 mg, 0.06 mmol) and 5-(benzo[d][1,3]dioxol-5-yl)-5-methylimidazolidine-2,4-dione (46.8 mg, 0.20 mmol), and stirred overnight. The reaction solution was added with water, extracted with ethyl acetate, subsequently dried using anhydrous sodium sulfate and concentrated in vacuo. The obtained residue was purified using silica-gel column chromatography (hexane:ethyl acetate), and the title compound (22.5 mg, yield 49%) was obtained as a colorless oil.

후처리

  1. extractionextracted with ethyl acetate
  2. customsubsequently dried
  3. concentrationconcentrated in vacuo
  4. customThe obtained residue was purified

출처 및 근거

ORD 기록
ord-ed7a1e0cdd7746e09c3c6b4a552f77ea
출처 데이터셋
uspto-grants-2011_08
특허 번호
US08008306B2

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