Potassium Carbonate → 2-Isopropyl-4-methoxy-5-thiazol-4-yl-phenol

HRID 1677314노트

반응식

HRID 1677314 반응식
[CH:1]([C:4]1[C:9](S(C2C=CC(C)=CC=2)(=O)=O)=[CH:8][C:7]([C:20]2[N:21]=[CH:22][S:23][CH:24]=2)=[C:6]([O:25][CH3:26])[CH:5]=1)([CH3:3])[CH3:2].C([O-])([O-])=[O:28].[K+].[K+]>CO>[CH:1]([C:4]1[CH:5]=[C:6]([O:25][CH3:26])[C:7]([C:20]2[N:21]=[CH:22][S:23][CH:24]=2)=[CH:8][C:9]=1[OH:28])([CH3:3])[CH3:2]

참가 물질

4

반응물 2

HCID 11430Potassium CarbonateHCID 595986244-[4-Isopropyl-2-methoxy-5-(toluene-4-sulfonyl)-phenyl]-thiazole

생성물 1

HCID 595986332-Isopropyl-4-methoxy-5-thiazol-4-yl-phenol

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

A mixture of 4-[4-Isopropyl-2-methoxy-5-(toluene-4-sulfonyl)-phenyl]-thiazole (1.0 g, 2.27 mmol) and K2CO3 (1.6 g, 11.34 mmol) in anhydrous MeOH (10 ml) was refluxed for 8 hrs. Solvent was removed in vacuo and the residue was partitioned between methylene chloride and water. The combined organic extract was dried over Na2SO4, filtered, and concentrated to give 2-Isopropyl-4-methoxy-5-thiazol-4-yl-phenol.

후처리

  1. temperaturewas refluxed for 8 hrs
  2. customSolvent was removed in vacuo
  3. customthe residue was partitioned between methylene chloride and water
  4. extractionThe combined organic extract
  5. dry with materialwas dried over Na2SO4
  6. filtrationfiltered
  7. concentrationconcentrated

출처 및 근거

ORD 기록
ord-1a9e0dd7b8564d439424007002d08d26
출처 데이터셋
uspto-grants-2011_08
특허 번호
US08008313B2

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