Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
3-Isopropoxybenzeneboronic acid → 1-[2-(3-Isopropoxy-phenyl)-5H-pyrrolo[2,3-b]pyrazin-7-yl]-2,2-dimethyl-propan-1-one
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 3-Isopropoxybenzeneboronic acid | HCID 5083932 | — |
| 반응물 | 1-(2-Bromo-5H-pyrrolo[2,3-b]pyrazin-7-yl)-2,2-dimethylpropan-1-one | HCID 57829218 | — |
| 용매 | Ethyl Acetate | HCID 8857 | — |
| 생성물 | 1-[2-(3-Isopropoxy-phenyl)-5H-pyrrolo[2,3-b]pyrazin-7-yl]-2,2-dimethyl-propan-1-one | HCID 59540779 | — |
반응 단계
1-[2-(3-Isopropoxy-phenyl)-5H-pyrrolo[2,3-b]pyrazin-7-yl]-2,2-dimethyl-propan-1-one was prepared starting from 1-(2-bromo-5H-pyrrolo[2,3-b]pyrazin-7-yl)-2,2-dimethyl-propan-1-one and 3-Isopropoxybenzeneboronic acid following general procedures as described in these Examples. Silica gel chromatography using 30-70% EtOAc in hexanes as eluant provided 140 mg (82%) of a yellow solid. MP 149-150° C., M+H=338
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08008298B2 |
| 출처 데이터셋 | uspto-grants-2011_08 |
| ORD ID | ord-e4a254b6bfbf45b79848fa27222692ef |
| 출처 메모 | uspto-grants-2011_08 |