3-(Aminosulphonyl)benzeneboronic acid → HCID 59540638, 화합물

HRID 1677448노트

반응식

HRID 1677448 반응식
Br[C:2]1[N:3]=[C:4]2[C:10]([C:11](=[O:16])[C:12]([CH3:15])([CH3:14])[CH3:13])=[CH:9][NH:8][C:5]2=[N:6][CH:7]=1.[NH2:17][S:18]([C:21]1[CH:22]=[C:23](B(O)O)[CH:24]=[CH:25][CH:26]=1)(=[O:20])=[O:19]>CCOC(C)=O>[CH3:13][C:12]([CH3:15])([CH3:14])[C:11]([C:10]1[C:4]2[C:5](=[N:6][CH:7]=[C:2]([C:25]3[CH:26]=[C:21]([S:18]([NH2:17])(=[O:20])=[O:19])[CH:22]=[CH:23][CH:24]=3)[N:3]=2)[NH:8][CH:9]=1)=[O:16]

참가 물질

4

반응물 2

HCID 441193233-(Aminosulphonyl)benzeneboronic acidHCID 578292181-(2-Bromo-5H-pyrrolo[2,3-b]pyrazin-7-yl)-2,2-dimethylpropan-1-one

생성물 1

HCID 59540638HCID 59540638, 화합물

시약·촉매·용매 1

HCID 8857Ethyl Acetate용매

실험 절차

3-[7-(2,2-Dimethyl-propionyl)-5H-pyrrolo[2,3-b]pyrazin-2-yl]-benzenesulfonamide was prepared starting from 1-(2-bromo-5H-pyrrolo[2,3-b]pyrazin-7-yl)-2,2-dimethyl-propan-1-one and (3-aminosulfonylphenyl)Boronic Acid following general procedures as described in these Examples. Silica gel chromatography using 20-100% EtOAc in hexanes as eluant provided 60 mg (37%) of a pale yellow solid. MP 275-277° C., M+H=359.

출처 및 근거

ORD 기록
ord-f77e56c40f2d4b919929f1bba60e7fe1
출처 데이터셋
uspto-grants-2011_08
특허 번호
US08008298B2

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