Thionyl Chloride → 1-Methyl-cycloheptanecarbonyl chloride

반응식

[CH3:1][C:2]1([C:9]([OH:11])=O)[CH2:8][CH2:7][CH2:6][CH2:5][CH2:4][CH2:3]1.S(Cl)([Cl:14])=O>>[CH3:1][C:2]1([C:9]([Cl:14])=[O:11])[CH2:8][CH2:7][CH2:6][CH2:5][CH2:4][CH2:3]1

참가 물질

반응물 2

HCID 24386Thionyl Chloride

HCID 127574891-Methylcycloheptane-1-carboxylic acid

생성물 1

HCID 215354961-Methyl-cycloheptanecarbonyl chloride수율 99%

실험 절차

A solution of 1-methyl-cycloheptanecarboxylic acid (156 mg, 0.998 mmol) (Journal of Organic Chemistry (1982), 47(17), 3242-7) in thionyl chloride (5 ml) was stirred at room temperature for 2 days and then concentrated on high vacuum giving 174 mg (99%) of 1-methyl-cycloheptanecarbonyl chloride as a yellow oil.

후처리

concentrationconcentrated on high vacuum

출처 및 근거

ORD 기록: ord-43cd66044f5f4b11b68e96d62e7621d2
출처 데이터셋: uspto-grants-2011_08
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US08008298B2

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