1-Adamantanecarbonyl chloride → Adamantan-1-yl-(2-bromo-5H-pyrrolo[2,3-b]pyrazin-7-yl)-methanone

반응식

[Br:1][C:2]1[N:3]=[C:4]2[CH:10]=[CH:9][NH:8][C:5]2=[N:6][CH:7]=1.[C:11]12([C:21](Cl)=[O:22])[CH2:20][CH:15]3[CH2:16][CH:17]([CH2:19][CH:13]([CH2:14]3)[CH2:12]1)[CH2:18]2>>[C:11]12([C:21]([C:10]3[C:4]4[C:5](=[N:6][CH:7]=[C:2]([Br:1])[N:3]=4)[NH:8][CH:9]=3)=[O:22])[CH2:18][CH:17]3[CH2:16][CH:15]([CH2:14][CH:13]([CH2:19]3)[CH2:12]1)[CH2:20]2

참가 물질

반응물 2

HCID 989151-Adamantanecarbonyl chloride

HCID 250673082-bromo-5H-pyrrolo[2,3-b]pyrazine

생성물 1

HCID 44182410Adamantan-1-yl-(2-bromo-5H-pyrrolo[2,3-b]pyrazin-7-yl)-methanone

실험 절차

Adamantan-1-yl-(2-bromo-5H-pyrrolo[2,3-b]pyrazin-7-yl)-methanone was prepared starting from 2-bromo-5H-pyrrolo[2,3-b]pyrazine and adamantane-1-carbonyl chloride following general procedures as described in these Examples. MP 279-280° C., M+H=360.

출처 및 근거

ORD 기록: ord-7c44bc719ca64c259966457955decaf9
출처 데이터셋: uspto-grants-2011_08
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US08008298B2

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