1,2-Dichloroethane → HCID 67374131, 화합물

HRID 1677609

반응식

HRID 1677609 반응식
[CH2:1]([O:8][C:9]([NH:11][CH:12]([P:16]([OH:18])[OH:17])[CH:13]([CH3:15])[CH3:14])=[O:10])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[CH2:19](Cl)[CH2:20]Cl>C(O)C.C(Cl)Cl>[CH2:19]([O:18][P:16]([CH:12]([NH:11][C:9]([O:8][CH2:1][C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1)=[O:10])[CH:13]([CH3:15])[CH3:14])[OH:17])[CH3:20]

참가 물질

5

반응물 2

HCID 111,2-DichloroethaneHCID 213258521-Carbobenzyloxyamino-2-methylpropanephosphonous acid

생성물 1

HCID 67374131HCID 67374131, 화합물수율 96.8%

시약·촉매·용매 2

HCID 702Ethanol용매HCID 6344Dichloromethane용매

실험 절차

To a solution of 1-(benzyloxycarbonylamino)-2-methylpropylphosphonous acid (5.8 g, 21.4 mmol) in 15 mL ethanol and 200 mL CH2Cl2 was added EDC (5.0 g, 26 mmol). The resulting reaction mixture was stirred at ambient temperature for 30 minutes. The mixture was concentrated in vacuo, and the residue was taken up into 200 mL ethyl acetate, washed with water and brine. The solvent was evaporated in vacuo to afford 1-(benzyloxycarbonylamino)-2-methylpropylphosphonous acid ethyl ester (6.2 g, 20.7 mmol, 96.8%) as white solid which was used without further purification.

후처리

  1. customThe resulting reaction mixture
  2. concentrationThe mixture was concentrated in vacuo
  3. washwashed with water and brine
  4. customThe solvent was evaporated in vacuo

출처 및 근거

ORD 기록
ord-5cdb2f8cf7d84ef9827e13655a9d5e5f
출처 데이터셋
uspto-grants-2011_08
특허 번호
US08008325B2

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