Trifluoroacetic acid → 2-(4-Aminophenyl)-3-(acetylthio)propanoic acid ethyl ester

HRID 1677611노트

반응식

HRID 1677611 반응식
[CH2:1]([O:3][C:4](=[O:28])[CH:5]([C:11]1[CH:16]=[CH:15][C:14]([NH:17]C(OCC2C=CC=CC=2)=O)=[CH:13][CH:12]=1)[CH2:6][S:7][C:8](=[O:10])[CH3:9])[CH3:2].FC(F)(F)C(O)=O>C(Cl)Cl>[CH2:1]([O:3][C:4](=[O:28])[CH:5]([C:11]1[CH:16]=[CH:15][C:14]([NH2:17])=[CH:13][CH:12]=1)[CH2:6][S:7][C:8](=[O:10])[CH3:9])[CH3:2]

참가 물질

4

반응물 2

HCID 6422Trifluoroacetic acidHCID 86608784HCID 86608784, 화합물

생성물 1

HCID 866087852-(4-Aminophenyl)-3-(acetylthio)propanoic acid ethyl ester수율 85%

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

To a solution of 2-(4-(benzyloxycarbonylamino)phenyl)-3-(acetylthio)-propanoic acid ethyl ester (0.2 g, 0.54 mmol) in 5 mL of methylene chloride was added 5 mL of trifluoroacetic acid. After 0.5 hours, the reaction mixture was concentrated in vacuo. The compound was purified by flash chromatography through silica gel (1/1 hexanes/ethyl acetate) to afford 2-(4-aminophenyl)-3-(acetylthio)propanoic acid ethyl ester (0.12 g, 85%).

후처리

  1. concentrationthe reaction mixture was concentrated in vacuo
  2. customThe compound was purified by flash chromatography through silica gel (1/1 hexanes/ethyl acetate)

출처 및 근거

ORD 기록
ord-f43231db2e964a21af3852bb74f95b32
출처 데이터셋
uspto-grants-2011_08
특허 번호
US08008325B2

반응 노트

불러오는 중…