4-(5H-pyrrolo[1,2-c]imidazol-7-yl)benzonitrile → HCID 16749887, 화합물

HRID 1677654

반응식

HRID 1677654 반응식
[CH:1]1[N:5]=[CH:4][N:3]2[CH2:6][CH:7]=[C:8]([C:9]3[CH:16]=[CH:15][C:12]([C:13]#[N:14])=[CH:11][CH:10]=3)[C:2]=12>CO.[Pd]>[CH:1]1[N:5]=[CH:4][N:3]2[CH2:6][CH2:7][CH:8]([C:9]3[CH:16]=[CH:15][C:12]([C:13]#[N:14])=[CH:11][CH:10]=3)[C:2]=12

참가 물질

4

반응물 1

HCID 669338694-(5H-pyrrolo[1,2-c]imidazol-7-yl)benzonitrile

생성물 1

HCID 16749887HCID 16749887, 화합물

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 887Methanol용매

실험 절차

A solution of 0.99 mmol of 4-(5H-pyrrolo[1,2-c]imidazol-7-yl)benzonitrile in 15 ml of MeOH is hydrogenated in the presence of 123 mg of 10% Pd/C at room temperature for 5.5 hours. The reaction mixture is subjected to clarifying filtration and the filtrate is evaporated. From the residue the title compound is obtained by means of flash chromatography (SiO2 60F) as a-pale reddish solid. Rf=0.22 (dichloromethane/ammonia (2M in EtOH) 97:3), Rt=4.43 (Gradient I).

후처리

  1. filtrationfiltration
  2. customthe filtrate is evaporated

출처 및 근거

ORD 기록
ord-00dad5054bce4742a03a1d72cf2f63cb
출처 데이터셋
uspto-grants-2011_08
특허 번호
US08008334B2

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