참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Water | HCID 962 | — |
| 반응물 | Lithium hydroxide, monohydrate | HCID 168937 | — |
| 반응물 | Methyl 4-(cis-2-phenyl-1-cyclohexanoyloxy)-2-methoxybenzoate | HCID 22883080 | — |
| 용매 | Tetrahydrofuran | HCID 8028 | — |
| 생성물 | 4-(cis-2-Phenyl-1-cyclohexanoyloxy)-2-methoxy-benzoic acid | HCID 22883078 | — |
반응 단계
To a stirred solution of methyl 4-(cis-2-phenyl- 1-cyclohexanoyloxy)-2-methoxybenzoate (230 mg, 0.64 mmol) in THF:H2O (5 mL:1 mL) was added LiOH.H2O (113.5 mg, 2.7 mmol). The reaction was heated to 45° C. over 12 h and then cooled to ambient temperature. The solvent was removed under reduced pressure. The crude solid was passed through a small plug of silca gel packed in 90:10 CH2Cl2 :MeOH(NH3) and eluted with same. The solvent was removed under reduced pressure to afford 4-(cis-2-phenyl-1-cyclohexanoyloxy)-2-methoxy-benzoic acid as a foam.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| 특허 번호 | US05726172 |
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| 출처 데이터셋 | uspto-grants-1998_03 |
|---|
| ORD ID | ord-9cf6d25d3c4e47a1a40710053bd23b71 |
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| 출처 메모 | uspto-grants-1998_03 |
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