Piperidine → 2-(Piperidin-1-yl)-1-phenyl-1H-indole-3-carboxaldehyde

HRID 1678119

반응식

HRID 1678119 반응식
Cl[C:2]1[N:3]([C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=2)[C:4]2[C:9]([C:10]=1[CH:11]=[O:12])=[CH:8][CH:7]=[CH:6][CH:5]=2.[NH:19]1[CH2:24][CH2:23][CH2:22][CH2:21][CH2:20]1>>[N:19]1([C:2]2[N:3]([C:13]3[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=3)[C:4]3[C:9]([C:10]=2[CH:11]=[O:12])=[CH:8][CH:7]=[CH:6][CH:5]=3)[CH2:24][CH2:23][CH2:22][CH2:21][CH2:20]1

참가 물질

3

반응물 2

HCID 8082PiperidineHCID 3147932-chloro-1-phenyl-1H-indole-3-carbaldehyde

생성물 1

HCID 597547562-(Piperidin-1-yl)-1-phenyl-1H-indole-3-carboxaldehyde수율 50%

실험 절차

2-Chloro-1-phenyl-1H-indole-3-carboxaldehyde is reacted with piperidine as described in Example 2 to give, after flash chromatography, the title compound (50% yield). NMR (CDCl3) 10.23 (1H, s), 8.29 (1H, d), 7.59 (2H, m), 7.50 (1H, m), 7.40 (2H, d), 7.22 (1H, m), 7.11 (1H, t), 6.98 (1H, d), 3.25 (4H, m), 1.53 (2H, m), 1.42 (4H, m).

후처리

  1. customto give

출처 및 근거

ORD 기록
ord-bc40dd90ecba47cbbf1ad49d4d6e1b68
출처 데이터셋
uspto-grants-2011_08
특허 번호
US08008491B2

연결된 노트

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