Piperazine → HCID 11381599, 화합물

반응식

Cl[C:2]1[N:3]([CH2:13][C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)[C:4]2[C:9]([C:10]=1[CH:11]=[O:12])=[CH:8][CH:7]=[CH:6][CH:5]=2.[NH:20]1[CH2:25][CH2:24][NH:23][CH2:22][CH2:21]1>>[N:20]1([C:2]2[N:3]([CH2:13][C:14]3[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=3)[C:4]3[C:9]([C:10]=2[CH:11]=[O:12])=[CH:8][CH:7]=[CH:6][CH:5]=3)[CH2:25][CH2:24][NH:23][CH2:22][CH2:21]1

참가 물질

반응물 2

HCID 4837Piperazine

HCID 105639332-Chloro-1-benzyl-1H-indole-3-carboxaldehyde

생성물 1

HCID 11381599HCID 11381599, 화합물수율 64%

실험 절차

2-Chloro-1-benzyl-1H-indole-3-carboxaldehyde (1.0 g, 5.5 mmol) is reacted with piperazine as described in Example 2 to yield the title compound (64%), mp 163-165° C., as a pale yellow solid. MS 320 (M+H).

출처 및 근거

ORD 기록: ord-0553973c8fae4207a334a49820e35a99
출처 데이터셋: uspto-grants-2011_08
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US08008491B2

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