2-chloro-1H-indole-3-carbaldehyde → HCID 86035888, 화합물

HRID 1678169노트

반응식

HRID 1678169 반응식
[Cl:1][C:2]1[NH:3][C:4]2[C:9]([C:10]=1[CH:11]=[O:12])=[CH:8][CH:7]=[CH:6][CH:5]=2.[CH:13]([C:15]1[CH:16]=[C:17](B(O)O)[CH:18]=[CH:19][CH:20]=1)=[O:14]>>[Cl:1][C:2]1[N:3]([C:19]2[CH:18]=[CH:17][CH:16]=[C:15]([CH:13]=[O:14])[CH:20]=2)[C:4]2[C:9]([C:10]=1[CH:11]=[O:12])=[CH:8][CH:7]=[CH:6][CH:5]=2

참가 물질

3

반응물 2

HCID 3147912-chloro-1H-indole-3-carbaldehydeHCID 27343563-Formylphenylboronic acid

생성물 1

HCID 86035888HCID 86035888, 화합물수율 99%

실험 절차

2-Chloro-1H-indole-3-carboxaldehyde is reacted with 3-formylphenylboronic acid as described in Step 1 of Example 29 to afford 2-chloro-1-(3-formylphenyl)-1H-indole-3-carboxaldehyde (99% yield) as a white solid. ESI/MS 284 (M+H); RT=3.37 min; NMR 10.15 (1H, s); 10.12 (1H, s); 8.23 (3H, m); 7.98 (2H, m); 7.41 (2H, m); 7.18 (1H, d, J=9 Hz).

출처 및 근거

ORD 기록
ord-fdd3efdb88964209ae84a1ce09d9361a
출처 데이터셋
uspto-grants-2011_08
특허 번호
US08008491B2

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