홈MCP워크벤치Skills
홈워크벤치알림마이페이지
llms.txt · MCP 가이드개인정보처리방침 · 이용약관 · 지원v1.8.0
  1. 홈
  2. /반응

[4-(4-Benzyloxycarbonylaminobutyl)phenoxy]acetic acid 2-tert-butoxycarbonylamino-ethyl ester → [4-(4-Aminobutyl)phenoxy]acetic acid 2-tert-butoxycarbonylaminoethyl ester ethyl acetate

HRID 1678303
노트
인쇄 미리보기

반응식

HRID 1678303 반응식
[C:1]([O:5][C:6]([NH:8][CH2:9][CH2:10][O:11][C:12](=[O:36])[CH2:13][O:14][C:15]1[CH:20]=[CH:19][C:18]([CH2:21][CH2:22][CH2:23][CH2:24][NH:25]C(OCC2C=CC=CC=2)=O)=[CH:17][CH:16]=1)=[O:7])([CH3:4])([CH3:3])[CH3:2]>C(O)(=O)C.C(OCC)(=O)C.ClCCl.[OH-].[OH-].[Pd+2]>[CH2:10]([O:11][C:12](=[O:36])[CH3:13])[CH3:9].[C:1]([O:5][C:6]([NH:8][CH2:9][CH2:10][O:11][C:12](=[O:36])[CH2:13][O:14][C:15]1[CH:16]=[CH:17][C:18]([CH2:21][CH2:22][CH2:23][CH2:24][NH2:25])=[CH:19][CH:20]=1)=[O:7])([CH3:4])([CH3:2])[CH3:3]
참가 물질실험 절차후처리출처 및 근거반응 노트

참가 물질

6

반응물 1

HCID 67350250[4-(4-Benzyloxycarbonylaminobutyl)phenoxy]acetic acid 2-tert-butoxycarbonylamino-ethyl ester

생성물 1

HCID 67351832[4-(4-Aminobutyl)phenoxy]acetic acid 2-tert-butoxycarbonylaminoethyl ester ethyl acetate수율 137.5%

시약·촉매·용매 4

HCID 176Acetic Acid촉매HCID 9942167Palladium hydroxide촉매HCID 6344Dichloromethane
용매
HCID 8857Ethyl Acetate용매

실험 절차

A solution of [4-(4-benzyloxycarbonylaminobutyl)phenoxy]acetic acid 2-tert-butoxycarbonylaminoethyl ester 44a (162 mg, 0.32 mmol) and acetic acid (3 drops) in ethyl acetate (3 mL) and dichloromethane (6 mL) was stirred at room temperature for 16 h under hydrogen atmosphere in the presence of palladium hydroxide on activated charcoal (80 mg, 60% wet). The catalyst was removed by suction filtration and the liquid filtrate was concentrated in vacuo to give [4-(4-aminobutyl)phenoxy]acetic acid 2-tert-butoxycarbonylaminoethyl ester ethyl acetate 45a as an off-white solid (100 mg, 84% yield) which was used directly without purification. m/z (ESI) 367 [C19H30N2O5+H]+.

후처리

  1. customThe catalyst was removed by suction filtration
  2. concentrationthe liquid filtrate was concentrated in vacuo

출처 및 근거

ORD 기록
ord-83cf993808fb4c1fab8c8c498394573d
출처 데이터셋
uspto-grants-2011_08
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US08008494B2

반응 노트

불러오는 중…

이 페이지에서참가 물질실험 절차후처리출처 및 근거반응 노트