5-Phenyl-2-furaldehyde → 3-(3-((5-Phenylfuran-2-yl)methylene)-3,4,5,6-tetrahydropyridin-2-yl)pyridine dihydrochloride

HRID 1678321

반응식

HRID 1678321 반응식
[Cl-:1].[NH3+:2][CH2:3][CH2:4][CH2:5][CH2:6][C:7]([C:9]1[CH:10]=[NH+:11][CH:12]=[CH:13][CH:14]=1)=O.[Cl-].[C:16]1([C:22]2[O:26][C:25]([CH:27]=O)=[CH:24][CH:23]=2)[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1>C(O)(C)C>[ClH:1].[ClH:1].[C:16]1([C:22]2[O:26][C:25]([CH:27]=[C:6]3[CH2:5][CH2:4][CH2:3][N:2]=[C:7]3[C:9]3[CH:10]=[N:11][CH:12]=[CH:13][CH:14]=3)=[CH:24][CH:23]=2)[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1

참가 물질

4

반응물 2

HCID 27694205-Phenyl-2-furaldehydeHCID 673376573-(5-Ammoniopentanoyl)pyridinium chloride

생성물 1

HCID 673394513-(3-((5-Phenylfuran-2-yl)methylene)-3,4,5,6-tetrahydropyridin-2-yl)pyridine dihydrochloride수율 181.8%

시약·촉매·용매 1

HCID 3776Isopropanol용매

반응 조건

온도
85 °C

실험 절차

3-(5-Ammoniopentanoyl)pyridinium chloride (188 mg, 0.75 mmol) was transferred to a reaction vessel and treated with isopropanol (12 mL). 5-Phenyl-2-furaldehyde (193 mg, 1.12 mmol) was added, the reaction vessel was sealed, and the reaction was heated to 85° C. with stirring for 6 hours. The reaction was then cooled to room temperature, and the precipitate was recovered by vacuum filtration, washed with isopropanol and ether then dried under vacuum giving 264 mg (91%) of an orange solid. LC-MS: RT=5.15 min, [M+H]+=315.1.

후처리

  1. customthe reaction vessel was sealed
  2. temperatureThe reaction was then cooled to room temperature
  3. filtrationthe precipitate was recovered by vacuum filtration
  4. washwashed with isopropanol and ether
  5. customthen dried under vacuum

출처 및 근거

ORD 기록
ord-75ab2f627f15424ab020297c32ceee07
출처 데이터셋
uspto-grants-2011_08
특허 번호
US08008499B2

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