Trifluoroacetic acid → N-{[2-(trifluoromethyl)phenyl]methyl}-4-piperidinecarboxamide

HRID 1678416노트

반응식

HRID 1678416 반응식
[F:1][C:2]([F:27])([F:26])[C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[CH2:9][NH:10][C:11]([CH:13]1[CH2:18][CH2:17][N:16](C(OC(C)(C)C)=O)[CH2:15][CH2:14]1)=[O:12].C(O)(C(F)(F)F)=O>C(Cl)Cl>[F:27][C:2]([F:1])([F:26])[C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[CH2:9][NH:10][C:11]([CH:13]1[CH2:18][CH2:17][NH:16][CH2:15][CH2:14]1)=[O:12]

참가 물질

4

반응물 2

HCID 6422Trifluoroacetic acidHCID 673389391,1-Dimethylethyl 4-[({[2-(trifluoromethyl)phenyl]methyl}amino)-carbonyl]-1-piperidinecarboxylate

생성물 1

HCID 59614575N-{[2-(trifluoromethyl)phenyl]methyl}-4-piperidinecarboxamide

시약·촉매·용매 1

HCID 6344Dichloromethane용매2회

반응 조건

온도
0 °C

실험 절차

To a solution of 1,1-dimethylethyl 4-[({[2-(trifluoromethyl)phenyl]methyl}amino)-carbonyl]-1-piperidinecarboxylate and CH2Cl2 (180 ml) at 0° C., a premixed solution of CH2Cl2 and TFA (180 ml) was added. The reaction mixture was stirred at 0° C. for 10 min and at room temperature for 2 h. The solvents were removed under reduced pressure to afford 11.9 g of the title compound. MS (ES+): m/e 287.9 [M+H]+.

후처리

  1. customThe solvents were removed under reduced pressure

출처 및 근거

ORD 기록
ord-935859e9cea74299aea1dafb5a93130f
출처 데이터셋
uspto-grants-2011_08
특허 번호
US08008483B2

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