Triethylamine → Furan-2-carboxylic acid [2-methyl-3'-(4-morpholin-4-yl-phenylcarbamoyl)-biphenyl-4-yl]-amide

HRID 1678460노트

반응식

HRID 1678460 반응식
[N:1]1([C:7]2[CH:12]=[CH:11][C:10]([NH:13][C:14]([C:16]3[CH:17]=[C:18]([C:22]4[CH:27]=[CH:26][C:25]([NH2:28])=[CH:24][C:23]=4[CH3:29])[CH:19]=[CH:20][CH:21]=3)=[O:15])=[CH:9][CH:8]=2)[CH2:6][CH2:5][O:4][CH2:3][CH2:2]1.C(N(CC)CC)C.[O:37]1[CH:41]=[CH:40][CH:39]=[C:38]1[C:42](Cl)=[O:43]>CN(C=O)C>[CH3:29][C:23]1[CH:24]=[C:25]([NH:28][C:42]([C:38]2[O:37][CH:41]=[CH:40][CH:39]=2)=[O:43])[CH:26]=[CH:27][C:22]=1[C:18]1[CH:19]=[CH:20][CH:21]=[C:16]([C:14](=[O:15])[NH:13][C:10]2[CH:9]=[CH:8][C:7]([N:1]3[CH2:6][CH2:5][O:4][CH2:3][CH2:2]3)=[CH:12][CH:11]=2)[CH:17]=1

참가 물질

5

반응물 3

HCID 8471TriethylamineHCID 682422-Furancarbonyl chlorideHCID 598223324'-Amino-2'-methyl-biphenyl-3-carboxylic acid (4-morpholin-4-yl-phenyl)-amide

생성물 1

HCID 59822350Furan-2-carboxylic acid [2-methyl-3'-(4-morpholin-4-yl-phenylcarbamoyl)-biphenyl-4-yl]-amide

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

A solution of 4′-amino-2′-methyl-biphenyl-3-carboxylic acid (4-morpholin-4-yl-phenyl)-amide (40 mg) and triethylamine (0.4 ml) in dry DMF (3 ml) was treated with furan-2-carbonyl chloride (0.015 ml) and the mixture stirred at 20 C for 18 h. The mixture was then partitioned between water and dichloromethane. The dried extract was then evaporated and the residue purified on silica gel. Elution with dichloromethane:ethanol:0.880 ammonia; 400:8:1 gave a colourless foam (46 mg).

후처리

  1. customThe mixture was then partitioned between water and dichloromethane
  2. extractionThe dried extract
  3. customwas then evaporated
  4. customthe residue purified on silica gel
  5. washElution with dichloromethane

출처 및 근거

ORD 기록
ord-ff18a3670f254a9188c057238b9529d7
출처 데이터셋
uspto-grants-2011_08
특허 번호
US08008303B2

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