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Triethylamine → 2'-Chloro-5'-(3-cyclohexyl-ureido)-biphenyl-4-carboxylic acid ethyl ester

HRID 1678520
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인쇄 미리보기

반응식

HRID 1678520 반응식
[CH2:1]([O:3][C:4]([C:6]1[CH:11]=[CH:10][C:9]([C:12]2[CH:17]=[C:16]([NH2:18])[CH:15]=[CH:14][C:13]=2[Cl:19])=[CH:8][CH:7]=1)=[O:5])[CH3:2].[CH:20]1([N:26]=[C:27]=[O:28])[CH2:25][CH2:24][CH2:23][CH2:22][CH2:21]1.C(N(CC)CC)C>C1COCC1>[CH2:1]([O:3][C:4]([C:6]1[CH:11]=[CH:10][C:9]([C:12]2[CH:17]=[C:16]([NH:18][C:27]([NH:26][CH:20]3[CH2:25][CH2:24][CH2:23][CH2:22][CH2:21]3)=[O:28])[CH:15]=[CH:14][C:13]=2[Cl:19])=[CH:8][CH:7]=1)=[O:5])[CH3:2]
참가 물질실험 절차후처리출처 및 근거반응 노트

참가 물질

5

반응물 3

HCID 8471TriethylamineHCID 18502Cyclohexyl isocyanateHCID 598223745'-Amino-2'-chloro-biphenyl-4-carboxylic acid ethyl ester

생성물 1

HCID 673754852'-Chloro-5'-(3-cyclohexyl-ureido)-biphenyl-4-carboxylic acid ethyl ester수율 100%

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

A mixture of 5′-amino-2′-chloro-biphenyl-4-carboxylic acid ethyl ester (350 mg) and cyclohexyl isocyanate (0.32 ml) in dry THF (15 ml) containing triethylamine (0.62 ml) was stirred at room temp for 48 h. The mixture was then evaporated and the residue partitioned between water and DCM. The dried extracts were evaporated giving the crude title compound as a white solid (616 mg, >100%, contaminated with dicyclohexyl-urea)

후처리

  1. customThe mixture was then evaporated
  2. customthe residue partitioned between water and DCM
  3. customThe dried extracts were evaporated

출처 및 근거

ORD 기록
ord-db375e4ce321484687619e31dc600eb1
출처 데이터셋
uspto-grants-2011_08
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US08008303B2

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