(E)-3-(3-Fluoro-4-nitro-phenyl)-acrylic acid tert-butyl ester → Tert-butyl 3-(4-amino-3-fluorophenyl)propanoate

HRID 1678689노트

반응식

HRID 1678689 반응식
[C:1]([O:5][C:6](=[O:19])/[CH:7]=[CH:8]/[C:9]1[CH:14]=[CH:13][C:12]([N+:15]([O-])=O)=[C:11]([F:18])[CH:10]=1)([CH3:4])([CH3:3])[CH3:2]>C(OCC)(=O)C.[Pd]>[C:1]([O:5][C:6](=[O:19])[CH2:7][CH2:8][C:9]1[CH:14]=[CH:13][C:12]([NH2:15])=[C:11]([F:18])[CH:10]=1)([CH3:4])([CH3:2])[CH3:3]

참가 물질

4

반응물 1

HCID 66905416(E)-3-(3-Fluoro-4-nitro-phenyl)-acrylic acid tert-butyl ester

생성물 1

HCID 66905628Tert-butyl 3-(4-amino-3-fluorophenyl)propanoate수율 99.7%

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 8857Ethyl Acetate용매

실험 절차

A solution of (E)-3-(3-fluoro-4-nitro-phenyl)-acrylic acid tert-butyl ester (804 mg, 3.01 mmol) in ethyl acetate (10 ml) was hydrogenated on 10% palladium on charcoal for 30 min at 1.5 bar. The suspension was filtered, the filter cake washed with ethyl acetate and the filtrate evaporated and dried under high vacuum to give the product as light brown solid (713 mg, 3 mmol; 99%). This material was pure enough for the next step. MS: m/e=240.0 [M+H+].

후처리

  1. filtrationThe suspension was filtered
  2. washthe filter cake washed with ethyl acetate
  3. customthe filtrate evaporated
  4. customdried under high vacuum

출처 및 근거

ORD 기록
ord-c8269afe9235414fba1b306c988bdd23
출처 데이터셋
uspto-grants-2011_08
특허 번호
US08008505B2

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