2-Bromothiazole → ethyl 2-[3-fluoro-4-(N-thiazol-2-ylamino)phenyl]propionate

HRID 1678875노트

반응식

HRID 1678875 반응식
[F:1][C:2]1[CH:3]=[C:4]([CH:9]([CH3:15])[C:10]([O:12][CH2:13][CH3:14])=[O:11])[CH:5]=[CH:6][C:7]=1[NH2:8].Br[C:17]1[S:18][CH:19]=[CH:20][N:21]=1>C(Cl)Cl>[F:1][C:2]1[CH:3]=[C:4]([CH:9]([CH3:15])[C:10]([O:12][CH2:13][CH3:14])=[O:11])[CH:5]=[CH:6][C:7]=1[NH:8][C:17]1[S:18][CH:19]=[CH:20][N:21]=1

참가 물질

4

반응물 2

HCID 764302-BromothiazoleHCID 20364696Ethyl 2-(4-amino-3-fluorophenyl)propanoate

생성물 1

HCID 20364701ethyl 2-[3-fluoro-4-(N-thiazol-2-ylamino)phenyl]propionate수율 63.6%

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

A mixture of ethyl 2-(3-fluoro-4-aminophenyl)propionate (15 g) and 2-bromothiazole (11.7 g) is stirred at 150°-155° C for 15 minutes. The reaction mixture is dissolved in methylene chloride and the solution is washed with an aqueous solution of sodium hydrogen carbonate and dried. The solvent is evaporated. The residue is subjected to chromatography using alumina. From benzene eluate, ethyl 2-[3-fluoro-4-(N-thiazol-2-ylamino)phenyl]propionate (13.3 g) is obtained as oily substance boiling at 162°-164° C at 0.2 mmHg.

후처리

  1. washthe solution is washed with an aqueous solution of sodium hydrogen carbonate
  2. customdried
  3. customThe solvent is evaporated

출처 및 근거

ORD 기록
ord-0e350db437c540e2907730dbbb7eeeb8
출처 데이터셋
uspto-grants-1978_03
특허 번호
US04077968

반응 노트

불러오는 중…