Acetylene → 1-Vinyl-4,5,6,7-tetrahydroindole

HRID 1678890

반응식

HRID 1678890 반응식
[C:1]1(=[N:7]O)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.[CH2:9](P(=O)(CC)CC)[CH3:10].[CH:17]#[CH:18]>>[CH:17]([N:7]1[C:1]2[CH2:6][CH2:5][CH2:4][CH2:3][C:2]=2[CH:10]=[CH:9]1)=[CH2:18]

참가 물질

4

반응물 3

HCID 6326Acetylene2회HCID 7517Cyclohexanone OximeHCID 79061Triethylphosphine oxide

생성물 1

HCID 111593881-Vinyl-4,5,6,7-tetrahydroindole수율 24%

반응 조건

온도
70 °C

실험 절차

5 g of cyclohexanone oxime, 0.05 g of potassium tert.butylate and 0.5 g of triethylphosphine oxide are placed into a one-liter rotary autoclave which is filled with acetylene under the pressure of 12 atm and heated at the temperature of 70° C for 3 hours. After cooling, the autoclave is again filled with acetylene under the same pressure and again heated at 70° C for 3 hours. The resulting cooled mixture is extracted with dibutyl ether and the extract is distilled to give 1.4 g (yield of 24%) of 1-vinyl-4,5,6,7-tetrahydroindole.

후처리

  1. temperatureAfter cooling
  2. temperatureagain heated at 70° C for 3 hours
  3. temperatureThe resulting cooled mixture
  4. extractionis extracted with dibutyl ether
  5. distillationthe extract is distilled

출처 및 근거

ORD 기록
ord-e616d0d8ec1e4a57b2c970fd9f43f93e
출처 데이터셋
uspto-grants-1978_03
특허 번호
US04077975

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