Piperidine → HCID 20365141, 화합물

HRID 1678965노트

반응식

HRID 1678965 반응식
[CH2:1]1[C:9]2[C:4](=[CH:5][C:6]([CH2:10][CH2:11][CH2:12]Br)=[CH:7][CH:8]=2)[CH2:3][CH2:2]1.[NH:14]1[CH2:19][CH2:18][CH2:17][CH2:16][CH2:15]1>C1(C)C=CC=CC=1.CCOCC>[CH2:1]1[C:9]2[C:4](=[CH:5][C:6]([CH2:10][CH2:11][CH2:12][N:14]3[CH2:19][CH2:18][CH2:17][CH2:16][CH2:15]3)=[CH:7][CH:8]=2)[CH2:3][CH2:2]1

참가 물질

5

반응물 2

HCID 8082PiperidineHCID 126461775-(3-Bromopropyl)-2,3-dihydro-1H-indene

생성물 1

HCID 20365141HCID 20365141, 화합물

시약·촉매·용매 2

HCID 1140Toluene용매HCID 3283Diethyl Ether용매

실험 절차

The crude 3-(5-Indanyl)-1-bromopropane (13.0 g, 0.054 M) is dissolved in 200 ml toluene and treated with 50 g of piperidine. The mixture is heated under reflux overnight, then cooled and diluted with ether to precipitate salts. The salts are removed by filtration and the solvent removed from the filtrate in vacuo. The residue is distilled collecting 8.4 g (64%) of desired product boiling at 135°-140° (0.15 mm).

후처리

  1. temperatureThe mixture is heated
  2. temperatureunder reflux overnight
  3. temperaturecooled
  4. customto precipitate salts
  5. customThe salts are removed by filtration
  6. customthe solvent removed from the filtrate in vacuo
  7. distillationThe residue is distilled
  8. customcollecting 8.4 g (64%) of desired product boiling at 135°-140° (0.15 mm)

출처 및 근거

ORD 기록
ord-fdea2c3c3ea54cd0844fcb9d57b56bbb
출처 데이터셋
uspto-grants-1978_03
특허 번호
US04078066

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