N,N-Dimethyl-1,3-propanediamine → 2-Ethyl-8-isopropyl-5-morpholino-8H-pyrazolo[4',3':5,6]pyrido[3,4-e][1,2,4]triazolo[1,5-a]pyrimidine

HRID 1679039

반응식

HRID 1679039 반응식
[CH:1]([N:4]1[C:8]2=[N:9][CH:10]=[C:11]([C:15](OCC)=O)[C:12]([NH:13][NH2:14])=[C:7]2[CH:6]=[N:5]1)([CH3:3])[CH3:2].C([N:22]1[C:26]2=[N:27][CH:28]=[C:29]([C:33](OCC)=O)C(NN)=C2C=N1)C.C(OC(=NC#N)CC)C.C(OC=NC#N)C.[NH:54]1[CH2:59][CH2:58][O:57][CH2:56][CH2:55]1.CN(C)CCCN.C(C1N=C2NC(=O)C3C=NC4N(C(C)C)N=CC=4C=3N2N=1)C.ClC1C2C=NC3N(C(C)C)N=CC=3C=2N2N=C(CC)N=C2N=1>>[CH2:29]([C:28]1[N:27]=[C:26]2[N:22]=[C:15]([N:54]3[CH2:59][CH2:58][O:57][CH2:56][CH2:55]3)[C:11]3[CH:10]=[N:9][C:8]4[N:4]([CH:1]([CH3:2])[CH3:3])[N:5]=[CH:6][C:7]=4[C:12]=3[N:13]2[N:14]=1)[CH3:33]

참가 물질

9

반응물 8

HCID 7993N,N-Dimethyl-1,3-propanediamineHCID 8083MorpholineHCID 1623571-ethyl-4-hydrazino-1H-pyrazolo[3,4-b]pyridine-5-carboxylic acid, ethyl esterHCID 4283341-isopropyl-4-hydrazino-1H-pyrazolo[3,4-b]pyridine-5-carboxylic acid, ethyl esterHCID 9920370Methanimidic acid, N-cyano-, ethyl esterHCID 10820532ethyl N-cyanopropionimidateHCID 227585085-chloro-2-ethyl-8-isopropyl-8H-pyrazolo[4',3':5,6]pyrido[3,4-e][1,2,4]triazolo[1,5-a]pyrimidineHCID 1355938642-ethyl-8-isopropyl-4H-pyrazolo[4',3':5,6]pyrido[3,4-e][1,2,4]triazolo[1,5-a]pyrimidin-5(8H)-one

생성물 1

HCID 227585392-Ethyl-8-isopropyl-5-morpholino-8H-pyrazolo[4',3':5,6]pyrido[3,4-e][1,2,4]triazolo[1,5-a]pyrimidine

실험 절차

By substituting 1-isopropyl-4-hydrazino-1H-pyrazolo[3,4-b]pyridine-5-carboxylic acid, ethyl ester for the 1-ethyl-4-hydrazino-1H-pyrazolo[3,4-b]pyridine-5-carboxylic acid, ethyl ester and 1-ethoxypropylidene cyanamide for the ethoxymethylene cyanamide in part a and morpholine for the 3-dimethylaminopropylamine in part c of the procedure of Example 1, 2-ethyl-8-isopropyl-4H-pyrazolo[4',3':5,6]pyrido[3,4-e][1,2,4]triazolo[1,5-a]pyrimidin-5(8H)-one, 5-chloro-2-ethyl-8-isopropyl-8H-pyrazolo[4',3':5,6]pyrido[3,4-e][1,2,4]triazolo[1,5-a]pyrimidine and 2-ethyl-8-isopropyl-5-morpholino-8H-pyrazolo[4',3':5,6]pyrido[3,4-e][1,2,4]triazolo[1,5-a]pryimidine, respectively, are obtained.

후처리

  1. customrespectively, are obtained

출처 및 근거

ORD 기록
ord-91d27942147c4bfe83b528c2b5069496
출처 데이터셋
uspto-grants-1978_03
특허 번호
US04078064

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