Ethyl Acetate → HCID 12800846, 화합물

HRID 1679185노트

반응식

HRID 1679185 반응식
Br.[NH2:2][CH2:3][C:4]([O:6][CH2:7][C:8]1[CH:13]=[CH:12][C:11]([N+:14]([O-:16])=[O:15])=[CH:10][CH:9]=1)=[O:5].CCOC(C)=O.C([O-])([O-])=O.[K+].[K+]>O>[NH2:2][CH2:3][C:4]([O:6][CH2:7][C:8]1[CH:13]=[CH:12][C:11]([N+:14]([O-:16])=[O:15])=[CH:10][CH:9]=1)=[O:5]

참가 물질

5

반응물 3

HCID 8857Ethyl AcetateHCID 11430Potassium CarbonateHCID 20516785p-Nitrobenzyl glycinate hydrobromide

생성물 1

HCID 12800846HCID 12800846, 화합물수율 98%

시약·촉매·용매 1

HCID 962Water용매

실험 절차

p-Nitrobenzyl glycinate hydrobromide (7.15 g., 24.6 mMol) is suspended in H2O (15 ml.) and the mixture is layered with EtOAc (40 ml.). The mixture is cooled in ice and stirred while cold, saturated aqueous K2CO3 (6 ml.) is added. The layers are separated and the aqueous portion is extracted with more EtOAc (3 × 15 ml.). The combined EtOAc solution is dried over Na2SO4, filtered and evaporated in vacuo to provide p-nitrobenzyl glycinate (5.05 g., 24.0 mMol, 98% yield) as an off-white solid.

후처리

  1. temperatureThe mixture is cooled in ice
  2. additionis added
  3. customThe layers are separated
  4. extractionthe aqueous portion is extracted with more EtOAc (3 × 15 ml.)
  5. dry with materialThe combined EtOAc solution is dried over Na2SO4
  6. filtrationfiltered
  7. customevaporated in vacuo

출처 및 근거

ORD 기록
ord-85288bfa059f40b0938c92bc24766210
출처 데이터셋
uspto-grants-1978_03
특허 번호
US04079179

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