Sodium Carbonate → 3-[4-(2-Acetylhydrazino)phenyl]rhodanine

HRID 1679244

반응식

HRID 1679244 반응식
C(=O)([O-])[O-].[Na+].[Na+].C(CS[C:12](=[S:18])[S:13][CH2:14][C:15]([OH:17])=O)(O)=O.[C:19]([NH:22][NH:23][C:24]1[CH:29]=[CH:28][C:27]([NH2:30])=[CH:26][CH:25]=1)(=[O:21])[CH3:20]>O>[C:19]([NH:22][NH:23][C:24]1[CH:29]=[CH:28][C:27]([N:30]2[C:15](=[O:17])[CH2:14][S:13][C:12]2=[S:18])=[CH:26][CH:25]=1)(=[O:21])[CH3:20]

참가 물질

5

반응물 3

HCID 10340Sodium CarbonateHCID 806183,5-Dithia-4-thioxo-1,7-heptanedioic acidHCID 81068Acetic acid, 2-(4-aminophenyl)hydrazide

생성물 1

HCID 203621233-[4-(2-Acetylhydrazino)phenyl]rhodanine

시약·촉매·용매 1

HCID 962Water용매

실험 절차

Sodium carbonate (1.06g. 0.010 mole) was dissolved in water (100 ml). Bis(carboxymethyl)trithiocarbonate (4.52g, 0.02 mole) was added portionwise with vigorous stirring. When solution was complete, the reaction mixture was warmed to 80°-85° C and 1-acetyl-2-(4-aminophenyl)hydrazine (3.30 g, 0.020 moles) was added in one portion. The reaction mixture was heated with stirring for 11/2 hours, cooled to about 50°-60° C, then reheated at 80°-85° C. The product began to precipitate during reheating. After another 2 hours of heating the mixture was cooled to room temperature, chilled and filtered. The solid which was collected was washed with water and dried. Yield 2.95g (53%), mp 210°-213° C (dec).

후처리

  1. temperaturethe reaction mixture was warmed to 80°-85° C
  2. temperatureThe reaction mixture was heated
  3. temperaturecooled to about 50°-60° C
  4. customreheated at 80°-85° C
  5. customto precipitate
  6. temperatureAfter another 2 hours of heating the mixture
  7. temperaturechilled
  8. filtrationfiltered
  9. customThe solid which was collected
  10. washwas washed with water
  11. customdried

출처 및 근거

ORD 기록
ord-6aac6c739c0742c7af0af338a0779eee
출처 데이터셋
uspto-grants-1978_03
특허 번호
US04080207

연결된 노트

불러오는 중…