Water → 2-Chloro-1-(5-chloro-3-phenyl-2,3-dihydro-1H-indol-1-yl)ethan-1-one

HRID 1679277노트

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HRID 1679277 반응식
[Cl:1][CH2:2][C:3]([N:5]1[C:13]2[C:8](=[CH:9][CH:10]=[CH:11][CH:12]=2)[CH:7]([C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)[CH2:6]1)=[O:4].[Cl:20]Cl.O>C(O)(=O)C>[Cl:1][CH2:2][C:3]([N:5]1[C:13]2[C:8](=[CH:9][C:10]([Cl:20])=[CH:11][CH:12]=2)[CH:7]([C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)[CH2:6]1)=[O:4]

참가 물질

5

반응물 3

HCID 962WaterHCID 24526ChlorineHCID 213204582-Chloro-1-(3-phenyl-2,3-dihydro-1H-indol-1-yl)ethan-1-one

생성물 1

HCID 213204742-Chloro-1-(5-chloro-3-phenyl-2,3-dihydro-1H-indol-1-yl)ethan-1-one

시약·촉매·용매 1

HCID 176Acetic Acid용매

반응 조건

온도
15 °C

실험 절차

2.7 G of N-chloracetyl-3-phenylindoline was added with vigorous stirring to a solution of 0.77 g of chlorine in 10 ml of glacial acetic acid which had been cooled to 15° C. The temperature of the mixture which rose to 33° C was cooled down to room temperature and the mixture stirred for a further hour. The resulting solution was poured into 100 ml of cold water. The liquid was decanted from the gummy residue, which was subsequently crystallized from ethanol to give 1.9 g of crystalline N-chloracetyl-3-phenyl-5-chloroindoline having a melting point of 107°-9° C.

후처리

  1. customrose to 33° C
  2. temperaturewas cooled down to room temperature
  3. customThe liquid was decanted from the gummy residue, which
  4. customwas subsequently crystallized from ethanol

출처 및 근거

ORD 기록
ord-841df34102fb41e68da2759186f00ecd
출처 데이터셋
uspto-grants-1978_03
특허 번호
US04080330

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