Triethylamine → 1-[(1-Phenylethyl)sulfanyl]pyrrolidine-2,5-dione

HRID 1679285

반응식

HRID 1679285 반응식
Cl[N:2]1[C:6](=[O:7])[CH2:5][CH2:4][C:3]1=[O:8].[C:9]1([CH:15]([SH:17])[CH3:16])[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1.C(N(CC)CC)C>C1C=CC=CC=1>[CH3:16][CH:15]([S:17][N:2]1[C:6](=[O:7])[CH2:5][CH2:4][C:3]1=[O:8])[C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1

참가 물질

5

반응물 3

HCID 8471TriethylamineHCID 31398ChlorosuccinimideHCID 1418501-Phenylethanethiol

생성물 1

HCID 205546171-[(1-Phenylethyl)sulfanyl]pyrrolidine-2,5-dione수율 36.8%

시약·촉매·용매 1

HCID 241Benzene용매4회

실험 절차

To a suitable reactor equipped with temperature controlling means and stirring means, there are charged, while maintaining the temperature at about room temperature, N-chlorosuccinimide (about 0.30 mole) in 400 ml of benzene and 1-phenylethanethiol (about 0.30 mole) in 50 ml of benzene. After stirring the reaction mixture 10 minutes, triethylamine (0.32 mole) in 50 ml of benzene is added dropwise. The benzene mixture is stirred one hour and then filtered. The filtrate is washed three times with 250 ml portions of water and then subjected to vacuum with heating to strip off volatile components. A crystalline residue is recrystallized from ethanol to give 26 grams of N-(α-methylbenzylthio)succinimide, m.p. 121-125°C.

후처리

  1. customTo a suitable reactor equipped with temperature
  2. additionare charged
  3. temperaturewhile maintaining the temperature at about room temperature
  4. additionis added dropwise
  5. filtrationfiltered
  6. washThe filtrate is washed three times with 250 ml portions of water
  7. temperaturewith heating
  8. customA crystalline residue is recrystallized from ethanol

출처 및 근거

ORD 기록
ord-a910ef935e39498f9cd87e7681119e55
출처 데이터셋
uspto-grants-1978_03
특허 번호
US04080342

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