Isobutyl chloroformate → HCID 178512905, 화합물

HRID 1679645노트

반응식

HRID 1679645 반응식
[NH2:1][C@H:2]([C:10]([OH:12])=O)[CH2:3][CH2:4][CH2:5][NH:6][C:7](=[NH:9])[NH2:8].C(OC(N([N+]([O-])=O)[C@H](C(O)=O)CCCNC(=N)N)=O)(C)(C)C.C(Cl)(=O)OCC(C)C.[NH2:43][CH2:44][C:45]([NH2:47])=[O:46]>CN(C)C=O.O1CCCC1.C(N(CC)CC)C>[NH2:1][C@H:2]([C:10]([NH:43][CH2:44][C:45]([NH2:47])=[O:46])=[O:12])[CH2:3][CH2:4][CH2:5][NH:6][C:7](=[NH:9])[NH2:8]

참가 물질

8

반응물 4

HCID 62365Isobutyl chloroformateHCID 69020GlycinamideHCID 178418600HCID 178418600, 화합물HCID 178454196HCID 178454196, 화합물

생성물 1

HCID 178512905HCID 178512905, 화합물

시약·촉매·용매 3

HCID 6228Dimethylformamide용매2회HCID 8028Tetrahydrofuran용매HCID 8471Triethylamine용매

실험 절차

Protected arginine, i.e., tert-butyloxycarbonylnitro-arginine is dissolved in a suitable solvent such as dimethylformamide and tetrahydrofuran. The dissolved protected amino acid is then cooled to a temperature slightly below the freezing point (0° C), whereupon isobutyl chlorocarbonate and triethylamine is added with stirring. After a short period, glycinamide dissolved in dimethylformamide is added. The mixture is then permitted to warm to room temperature and stirred for a period of several hours and then filtered. The filtrate is recovered and evaporated to dryness and then extracted with dimethylformamide. The dimethylformamide solution is precipitated with ethylacetate to yield the dipeptide, i.e., protected arginyl-glycinamide.

후처리

  1. additionis added
  2. waitAfter a short period
  3. additionis added
  4. stirringstirred for a period of several hours
  5. filtrationfiltered
  6. customThe filtrate is recovered
  7. customevaporated to dryness
  8. extractionextracted with dimethylformamide
  9. customThe dimethylformamide solution is precipitated with ethylacetate

출처 및 근거

ORD 기록
ord-55a5380ecac242509ecaf254a4a52585
출처 데이터셋
uspto-grants-1978_03
특허 번호
US04081533

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