Trifluoroacetic acid → HCID 88813774, 화합물

반응식

[NH:1](C(OC(C)(C)C)=O)[C@H:2]([C:4]([NH:6][CH2:7][C:8]([O:10][CH3:11])=[O:9])=[O:5])[CH3:3].[F:19][C:20]([F:25])([F:24])[C:21]([OH:23])=[O:22]>>[F:19][C:20]([F:25])([F:24])[C:21]([OH:23])=[O:22].[CH3:11][O:10][C:8](=[O:9])[CH2:7][NH:6][C:4](=[O:5])[C@H:2]([CH3:3])[NH2:1]

참가 물질

반응물 2

HCID 6422Trifluoroacetic acid

HCID 14158799HCID 14158799, 화합물

생성물 1

HCID 88813774HCID 88813774, 화합물

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온도: 0 °C

실험 절차

Boc-Ala-Gly-OMe [10 g, 45 mmoles, described by H. U. Immer et al., Helv. Chim. Acta, 57, 730 (1974)] is dissolved in cold (ice bath) trifluoroacetic acid (100 ml). The solution is stirred for 1 hr at 0° C and the solvent evaporated. The residue is dissolved in methanol, added to diethyl ether and the precipitate collected to yield the title compound.

후처리

customthe solvent evaporated
dissolutionThe residue is dissolved in methanol
additionadded to diethyl ether
customthe precipitate collected

출처 및 근거

ORD 기록: ord-70b1e0cc27e8411d82ffa2ede26c0f25
출처 데이터셋: uspto-grants-1978_03
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US04081530

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