Z-Thr(tbu)-ome → (2S,3R)-Methyl 2-amino-3-(tert-butoxy)butanoate

HRID 1679829노트

반응식

HRID 1679829 반응식
[CH3:1][C@@H:2]([O:19][C:20]([CH3:23])([CH3:22])[CH3:21])[C@H:3]([NH:8]C(OCC1C=CC=CC=1)=O)[C:4]([O:6][CH3:7])=[O:5]>C(O)(=O)C.[C].[Pd]>[NH2:8][C@H:3]([C:4]([O:6][CH3:7])=[O:5])[C@@H:2]([CH3:1])[O:19][C:20]([CH3:23])([CH3:22])[CH3:21]

참가 물질

4

반응물 1

HCID 59113197Z-Thr(tbu)-ome

생성물 1

HCID 7018834(2S,3R)-Methyl 2-amino-3-(tert-butoxy)butanoate수율 96.4%

시약·촉매·용매 2

HCID 178418390HCID 178418390, 화합물촉매HCID 176Acetic Acid용매

실험 절차

12.92 Grams (40 mmols) of Z-Thr-(tBu)-OMe in 200 ml of glacial acetic acid and 3 g of palladium carbon (10% Pd) are hydrogenated at room temperature. The absorption of hydrogen ceases after one hour. The catalyst is filtered off and the filtrate evaporated at 35° C. in a water-jet vacuum. The residue is dried in a high vacuum at 35° C. and yields 7.3 g of an oil which is unitary according to its thin-layer chromatogram and can be further used as it is.

후처리

  1. customare hydrogenated at room temperature
  2. customThe absorption of hydrogen ceases after one hour
  3. filtrationThe catalyst is filtered off
  4. customthe filtrate evaporated at 35° C. in a water-jet vacuum
  5. customThe residue is dried in a high vacuum at 35° C.

출처 및 근거

ORD 기록
ord-7223f394e67d4e9f831bd7028814d954
출처 데이터셋
uspto-grants-1981_06
특허 번호
US04271068

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