Z-Gln-ONp → H-Gln-Thr-Pro-OtBu

HRID 1680052노트

반응식

HRID 1680052 반응식
[NH2:1][C@H:2]([C:6]([N:8]1[CH2:19][CH2:18][CH2:17][C@H:9]1[C:10]([O:12][C:13]([CH3:16])([CH3:15])[CH3:14])=[O:11])=[O:7])[C@@H:3]([CH3:5])[OH:4].C1C=CC(COC([NH:30][C@H:31]([C:37](OC2C=CC([N+]([O-])=O)=CC=2)=[O:38])[CH2:32][CH2:33][C:34]([NH2:36])=[O:35])=O)=CC=1>CN(C=O)C>[NH2:30][C@H:31]([C:37]([NH:1][C@H:2]([C:6]([N:8]1[CH2:19][CH2:18][CH2:17][C@H:9]1[C:10]([O:12][C:13]([CH3:15])([CH3:14])[CH3:16])=[O:11])=[O:7])[C@@H:3]([CH3:5])[OH:4])=[O:38])[CH2:32][CH2:33][C:34](=[O:35])[NH2:36]

참가 물질

4

반응물 2

HCID 111333Z-Gln-ONpHCID 131712118H-Thr-Pro-OtBu

생성물 1

HCID 131712117H-Gln-Thr-Pro-OtBu

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

1.36 g H-Thr-Pro-OtBu is dissolved in 10 ml DMF, after which 1.93 g Z-Gln-ONp is added and the reaction mixture is stirred for about 20 hours at room temperature. After evaporation of the mixture to dryness, the residue is dissolved in EtOAc and washed consecutively with 5% KHSO4 solution, 5% NaHCO3 solution and a saturated NaCl solution. The solution is then dried over Na2SO4 and filtered, and the filtrate is evaporated to dryness.

후처리

  1. customAfter evaporation of the mixture to dryness
  2. dissolutionthe residue is dissolved in EtOAc
  3. washwashed consecutively with 5% KHSO4 solution, 5% NaHCO3 solution
  4. dry with materialThe solution is then dried over Na2SO4
  5. filtrationfiltered
  6. customthe filtrate is evaporated to dryness

출처 및 근거

ORD 기록
ord-b22a67e408404ba19122d28e54dd56bc
출처 데이터셋
uspto-grants-1981_06
특허 번호
US04271152

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