Phosphorus pentachloride → N-(2,6-dichlorophenyl)-2,3-dihydro-2-oxothieno[3,4-b]pyrrole

HRID 1680171노트

반응식

HRID 1680171 반응식
[Cl:1][C:2]1[CH:17]=[CH:16][CH:15]=[C:14]([Cl:18])[C:3]=1[NH:4][C:5]1[C:6]([CH2:10][C:11](O)=[O:12])=[CH:7][S:8][CH:9]=1.P(Cl)(Cl)(Cl)(Cl)Cl>C1(C)C=CC=CC=1>[Cl:1][C:2]1[CH:17]=[CH:16][CH:15]=[C:14]([Cl:18])[C:3]=1[N:4]1[C:11](=[O:12])[CH2:10][C:6]2=[CH:7][S:8][CH:9]=[C:5]12

참가 물질

4

반응물 2

HCID 24819Phosphorus pentachlorideHCID 51717Eltenac

생성물 1

HCID 23457240N-(2,6-dichlorophenyl)-2,3-dihydro-2-oxothieno[3,4-b]pyrrole

시약·촉매·용매 1

HCID 1140Toluene용매

실험 절차

1 g (0.33 mmole) of 4-(2,6-dichloroanilino)-3-thiophenacetic acid and 0.7 g (0.33 mmole) of phosphorus pentachloride are stirred in 10 ml of toluene at room temperature for half an hour. The mixture is extracted with water and sodium bicarbonate solution, clarified with bleaching earth (for example Tonsil®) and concentrated. Recrystallization of the residue from isopropanol yields N-(2,6-dichlorophenyl)-2,3-dihydro-2-oxothieno[3,4-b]pyrrole (m. 187° to 188°).

후처리

  1. extractionThe mixture is extracted with water and sodium bicarbonate solution
  2. concentrationconcentrated
  3. customRecrystallization of the residue from isopropanol

출처 및 근거

ORD 기록
ord-142fa22fbd3b4f498e995f2f7de0a3d6
출처 데이터셋
uspto-grants-1981_06
특허 번호
US04272507

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