4-Chlorophenol → 4-Chlorophenyl 4-(hexadecylamino)benzoate

HRID 1680294노트

반응식

HRID 1680294 반응식
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([OH:8])=[CH:4][CH:3]=1.C(N(CC)CC)C.Cl.[CH2:17]([NH:33][C:34]1[CH:42]=[CH:41][C:37]([C:38](Cl)=[O:39])=[CH:36][CH:35]=1)[CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][CH2:27][CH2:28][CH2:29][CH2:30][CH2:31][CH3:32]>C(Cl)Cl>[CH2:17]([NH:33][C:34]1[CH:35]=[CH:36][C:37]([C:38]([O:8][C:5]2[CH:6]=[CH:7][C:2]([Cl:1])=[CH:3][CH:4]=2)=[O:39])=[CH:41][CH:42]=1)[CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][CH2:27][CH2:28][CH2:29][CH2:30][CH2:31][CH3:32]

참가 물질

5

반응물 3

HCID 46844-ChlorophenolHCID 8471TriethylamineHCID 132553224-Hexadecylaminobenzoyl chloride hydrochloride

생성물 1

HCID 234577774-Chlorophenyl 4-(hexadecylamino)benzoate

시약·촉매·용매 1

HCID 6344Dichloromethane용매2회

실험 절차

To a solution of 6.4 g. (50 m moles) 4-chlorophenol and 7.6 g. (75 m moles) triethylamine in 500 ml. methylene chloride is added 10.4 g. (25 m moles) 4-(hexadecylamino)benzoyl chloride hydrochloride in 250 ml. methylene chloride. After four hours at reflux, the solution is cooled, washed with water and dilute phosphoric acid, and dried. After passing the solution through a column of alumina, the solvent is evaporated and the residue is crystallized from diisopropyl ether.

후처리

  1. temperatureAfter four hours at reflux
  2. temperaturethe solution is cooled
  3. washwashed with water and dilute phosphoric acid
  4. customdried
  5. customthe solvent is evaporated
  6. customthe residue is crystallized from diisopropyl ether

출처 및 근거

ORD 기록
ord-2102fa1351e64616bfc0751ae4653970
출처 데이터셋
uspto-grants-1981_06
특허 번호
US04272546

반응 노트

불러오는 중…