m-Chloroperbenzoic acid → 2-Methyl-5-nitropyridine N-oxide

HRID 1680460노트

반응식

HRID 1680460 반응식
[N+:1]([C:4]1[CH:5]=[CH:6][C:7]([CH3:10])=[N:8][CH:9]=1)([O-:3])=[O:2].ClC1C=CC=C(C(OO)=[O:19])C=1>C(Cl)Cl>[N+:1]([C:4]1[CH:9]=[N+:8]([O-:19])[C:7]([CH3:10])=[CH:6][CH:5]=1)([O-:3])=[O:2]

참가 물질

4

반응물 2

HCID 70297m-Chloroperbenzoic acidHCID 27945522-Methyl-5-nitropyridine

생성물 1

HCID 127053092-Methyl-5-nitropyridine N-oxide

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

2.5 g of 5-nitro-2-picoline are dissolved in 60 ml of methylene chloride and 4.05 g (20 m mole) of 85% m-chloroperbenzoic acid are added while stirring at room temperature. Stirring is continued overnight and the mixture is washed twice with aqueous sodium bicarbonate and then with water. It is dried, evaporated and the residue crystallized from acetonitrile, to yield the 5-nitro-2-picoline-N-oxide melting at 149°-153°.

후처리

  1. stirringStirring
  2. washthe mixture is washed twice with aqueous sodium bicarbonate
  3. customIt is dried
  4. customevaporated
  5. customthe residue crystallized from acetonitrile

출처 및 근거

ORD 기록
ord-5c2c3dd16b1a40a7a718ab15c4821040
출처 데이터셋
uspto-grants-1981_06
특허 번호
US04273779

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