Imidazole → 2-(1H-Imidazol-1-yl)-1-(4-(2-phenylethyl)phenyl)ethanone

HRID 1680649노트

반응식

HRID 1680649 반응식
[NH:1]1[CH:5]=[CH:4][N:3]=[CH:2]1.Cl[CH2:7][C:8]([C:10]1[CH:15]=[CH:14][C:13]([CH2:16][CH2:17][C:18]2[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=2)=[CH:12][CH:11]=1)=[O:9].O>CN(C)C=O>[N:1]1([CH2:7][C:8]([C:10]2[CH:15]=[CH:14][C:13]([CH2:16][CH2:17][C:18]3[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=3)=[CH:12][CH:11]=2)=[O:9])[CH:5]=[CH:4][N:3]=[CH:2]1

참가 물질

5

반응물 3

HCID 795ImidazoleHCID 962WaterHCID 30087272-Chloro-1-[4-(2-phenylethyl)phenyl]ethan-1-one

생성물 1

HCID 527582-(1H-Imidazol-1-yl)-1-(4-(2-phenylethyl)phenyl)ethanone수율 77.4%

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

To a solution containing 3.4 g of imidazole in 5 ml of dimethylformamide, stirred at 0/+5° C., 2.58 g of 4-chloroacetyl-bibenzyl were slowly added. The reaction mixture was stirred for few minutes, then allowed to stand and then poured into water. The product thus formed was filtered off, purified by silica gel column chromatography (eluant: benzene/acetone) and then crystallized from ethyl acetate to give 2.24 g of the title compound melting at 134°-6° C. Yield 77%.

후처리

  1. additionwere slowly added
  2. customThe product thus formed
  3. filtrationwas filtered off
  4. custompurified by silica gel column chromatography (eluant: benzene/acetone)
  5. customcrystallized from ethyl acetate

출처 및 근거

ORD 기록
ord-e6e495a422b34154a5a1fc4db748d16f
출처 데이터셋
uspto-grants-1981_06
특허 번호
US04275071

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