Imidazole → Acetophenone, 2-(1-imidazolyl)-2',3',5',6'-tetramethyl-

HRID 1680650노트

반응식

HRID 1680650 반응식
Br[CH2:2][C:3]([C:5]1[C:11]([CH3:12])=[C:10]([CH3:13])[CH:9]=[C:7]([CH3:8])[C:6]=1[CH3:14])=[O:4].CN(C)C=O.[NH:20]1[CH:24]=[CH:23][N:22]=[CH:21]1>O>[N:20]1([CH2:2][C:3]([C:5]2[C:11]([CH3:12])=[C:10]([CH3:13])[CH:9]=[C:7]([CH3:8])[C:6]=2[CH3:14])=[O:4])[CH:24]=[CH:23][N:22]=[CH:21]1

참가 물질

5

반응물 3

HCID 795ImidazoleHCID 6228DimethylformamideHCID 2648242-bromo-1-(2,3,5,6-tetramethylphenyl)ethanone

생성물 1

HCID 52759Acetophenone, 2-(1-imidazolyl)-2',3',5',6'-tetramethyl-수율 62%

시약·촉매·용매 1

HCID 962Water용매

반응 조건

온도
80 °C

실험 절차

A mixture containing 2.55 g of 3-bromoacetyl-durene, prepared as described in Example 4, 3 ml of dimethylformamide and 3.40 g of imidazole, was stirred for 8 hours at 80° C. At the end of the reaction, the mixture was cooled to room temperature and 25 ml of water were added. The precipitate thus obtained was filtered off, dried and crystallized from benzene to give 1.5 g of the title compound. M.P. 176°-8° C., yield 62%.

후처리

  1. customprepared
  2. customAt the end of the reaction
  3. temperaturethe mixture was cooled to room temperature
  4. customThe precipitate thus obtained
  5. filtrationwas filtered off
  6. customdried
  7. customcrystallized from benzene

출처 및 근거

ORD 기록
ord-432d2bfa73a04984a77de39e461e182b
출처 데이터셋
uspto-grants-1981_06
특허 번호
US04275071

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